Make sure to prepare your hard drives, as a huge patch for Mass Effect 3 is set to arrive later today. BioWare's Michael Gamble tweeted the news, which is the "largest patch" for ME3 and has been in development for "months." The patch is designed to fix technical issues, gameplay exploits, and platform-specific problems (crashes, message pop-ups, enemy combat, multiplayer powers, and more). You can read the full list of fixes at the BioWare Social forums, but it may take you a little while to go through all of them. PC gamers can download the patch through Origin, while PS3 and 360 gamers will be prompted to update the game when they start it.
Interestingly, Gamble revealed this patch sets BioWare up for "future...things," however it is anyone's guess what those are. The Omega DLC is set to arrive later this year, as are other single player stories, so Gamble could just be hinting at those. Or it could be something else entirely. We just have to wait and see.