It seems GLaDOS has tired of Aperture Science and is moving on to a different environment to administer new tests. Defense Grid: The Awakening will be getting some new DLC called You Monster that features GLaDOS. There will be eight new maps and 35 challenge missions where GLaDOS will send wave of monsters at you while monitoring your progress. It will be interesting to see just what GLaDOS has in store for us in a tower defense game, but I am sure she has something devious cooking up. Nothing about GLaDOS says she has to play fair, so expect her to change the rules of Defense Grid at her discretion.
Defense Grid: You Monster launches on December 7th.